These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The structure and function of cadherins and their pathophysiological roles in diseases].
    Author: Koike T, Hamaguchi M.
    Journal: Nihon Rinsho; 1995 Jul; 53(7):1578-84. PubMed ID: 7629991.
    Abstract:
    Cadherins are a family of Ca(2+)-dependent cell adhesion molecules that mediate cell adhesion by homophilic interaction and play critical role in multicellular organ formation. Recent progress revealed the three-dimensional structure of extracellular cadherin repeats that made great progress in the study of cell adhesion by cadherins. The perturbation of cadherin function in transformed cells results in inhibition of cell-cell adhesion, that appears to promote metastasis and invasiveness of tumor cells. Expression as well as modifications of catenins, which link cadherins to cytoskeletons, have crucial effects on this purturbation mechanisms. Tyrosine phosphorylation of cadherin catenin complex may be the important regulatory mechanism.
    [Abstract] [Full Text] [Related] [New Search]