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  • Title: [The expression of MMPs and TIMPs in human breast cancer tissues and importance of their balance in cancer invasion and metastasis].
    Author: Iwata H, Kobayashi S, Iwase H, Okada Y.
    Journal: Nihon Rinsho; 1995 Jul; 53(7):1805-10. PubMed ID: 7630023.
    Abstract:
    Tumor cells degrade extracellular matrix components (ECM) to invade surrounding tissues. Malignant tumor cells are known to produce various ECM-degrading enzymes including matrix metalloproteinases (MMPs), serine proteinases and cathepsins. Among them, MMPs may play a key role in cancer invasion and metastasis. To study the role of MMPs in the progression of human breast carcinomas, we examined production and tissue localization of MMP-1, MMP-2, MMP-3, MMP-9 and their common inhibitors, tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2). The data suggest that the imbalance between MMPs and TIMPs produced by tumor tissues may be a determinant of the progression in breast carcinoma.
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