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  • Title: The Brucella abortus RB51 vaccine does not confer protection against Brucella ovis in rams.
    Author: Jiménez de Bagüés MP, Barberán M, Marín CM, Blasco JM.
    Journal: Vaccine; 1995 Feb; 13(3):301-4. PubMed ID: 7631517.
    Abstract:
    The protective efficacy against Brucella ovis of the live vaccine Brucella abortus strain RB51 has been evaluated in rams using the attenuated B. melitensis strain Rev 1 as a reference vaccine. Sixteen Brucella-free rams, 6 months of age, were vaccinated subcutaneously with 4.18 x 10(10) c.f.u. RB51. Sixteen rams of the same condition and age were vaccinated subcutaneously the same day with 1.1 x 10(9) c.f.u. Rev 1. Fifteen similar rams were kept unvaccinated as controls. Six months after vaccination all rams were challenged with 3 x 10(9) c.f.u. B. ovis and slaughtered 8 weeks thereafter for bacteriological and pathological studies. The percentage of rams that were found infected was 68% (Rev 1), 100% (RB51) and 100% (controls). At necropsy, the percentage of organs found to be infected was significantly lower (p < 0.0005) in Rev 1-vaccinated (34%) than in RB51-vaccinated rams (74%) or controls (69%). In conclusion, the RB51 vaccine did not confer protective immunity against B. ovis in rams.
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