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  • Title: Flow cytometric analysis of the DNA content of thymomas.
    Author: Kushibe K, Iioka S, Nezu K, Tojo T, Sawabata N, Kitamura S.
    Journal: Surg Today; 1995; 25(4):334-7. PubMed ID: 7633125.
    Abstract:
    In this study, the prognostic value of determining the nuclear DNA content of thymomas by flow cytometry was evaluated. Of a total 31 resected thymomas, 10 (32%) showed DNA aneuploidy, the presence of which was significantly correlated with an advanced clinical stage of disease. The patients with an aneuploid tumor had a poorer prognosis than those with a diploid tumor, demonstrating a survival rate of 50% at 7 postoperative years, which was considerably less favorable than that of the patients with a diploid tumor, being 100% in the same period (p < 0.05). Moreover, patients with a high DNA index (DI), i.e., a DI >or= 1.5, tended to have a poorer prognosis than those with a low DI. These findings indicated that the DNA content can be an important prognostic index in patients with thymomas.
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