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  • Title: Intermittent shedding of human immunodeficiency virus in semen: implications for sexual transmission.
    Author: Krieger JN, Coombs RW, Collier AC, Ho DD, Ross SO, Zeh JE, Corey L.
    Journal: J Urol; 1995 Sep; 154(3):1035-40. PubMed ID: 7637049.
    Abstract:
    PURPOSE: We attempt to increase our understanding of human immunodeficiency virus (HIV) shedding in semen. MATERIALS AND METHODS: We followed 16 seropositive men for up to 27 months by HIV cocultivation, with a subset evaluated using the polymerase chain reaction. RESULTS: The proportion with at least 1 HIV positive semen culture increased from 3 of 16 subjects (19%) at visit 1 to 10 (63%) by visit 5. Overall, HIV was cultured from 25 of 114 specimens (22%). Shedding was intermittent for each of the 10 men with at least 1 positive culture and seminal shedding patterns were highly variable. CONCLUSIONS: By culture and polymerase chain reaction, HIV is shed intermittently in the semen. If cultures are performed often enough most seropositive men shed HIV in the semen.
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