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  • Title: Polymorphic paracetamol conjugation: phenotyping in a Hungarian population.
    Author: Róna K, Ary K, Szüts I, Kovács L, Gachályi B.
    Journal: Acta Med Hung; 1994; 50(1-2):65-74. PubMed ID: 7638043.
    Abstract:
    The authors studied the distribution of the paracetamol conjugation in a Hungarian population (53 adult Caucasian persons). The data indicated that the excretion of paracetamol glucuronide and sulphate were not normally distributed. Bimodality were apparent in both conjugation pathways: 15.1% of subjects was relatively extensive glucuronidators, and the 24.5% of subjects was extensive sulphatators. Monitoring the ratios of various urinary paracetamol conjugates/paracetamol may be useful as a tool for determining the glucuronide and sulphate conjugation capacity in humans.
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