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  • Title: [Induced modifications of liver cytochrome P-450 levels as a function of age in rats].
    Author: Plewka A, Plewka D, Kamiński M.
    Journal: Postepy Hig Med Dosw; 1994; 48(4):457-70. PubMed ID: 7638096.
    Abstract:
    In this paper we showed age effect on hepatic level of cytochrome P-450. We discussed effects of inductors on this hemoprotein also. Cytochrome P-450 content increased to 1-month of life, but decreased to 4-month. In the oldest rats cytochrome P-450 increased again. Content of this hemoprotein was induced by phenobarbital and beta-naphthoflavone in all examined groups, especially strong in young animals. Induction effect of dexamethasone was observed in 4-20-month of life.
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