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  • Title: Taxol inhibits growth of mesothelioma xenografts.
    Author: Lee JM, Bruckner HW, Szrajer L, Brenne U, Schindelheim G, Andreotti PE.
    Journal: Anticancer Res; 1995; 15(3):693-6. PubMed ID: 7645945.
    Abstract:
    BACKGROUND: In vitro tests measuring inhibition of adenosine triphosphate activity predicted three mesothelioma xenografts would be sensitive to taxol. PURPOSE: The in vivo therapeutic efficacy of taxol was tested in nude mice carrying the subcutaneous tumors. METHODS: Once tumor growth reached 100mm3 in size, intraperitoneal taxol, 30 mg/kg, on a day 1, 4, and 8 schedule, was administered to mice bearing subcutaneous mesothelioma xenografts. RESULTS: Taxol inhibits the growth of all three cell lines. It produces actual tumor regression including some complete responses. CONCLUSIONS: Taxol is an active drug against mesothelioma. The in vitro cell lines and the in vivo system are useful tools for screening and developing new treatments for mesothelioma.
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