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  • Title: The Hancock II bioprosthesis at ten years.
    Author: David TE, Armstrong S, Sun Z.
    Journal: Ann Thorac Surg; 1995 Aug; 60(2 Suppl):S229-34. PubMed ID: 7646164.
    Abstract:
    The Hancock II bioprosthesis was used for heart valve replacement in 843 patients from 1982 to 1993. Aortic valve replacement (AVR) was performed in 536 patients, mitral valve replacement (MVR) in 250, and aortic and mitral valve replacement (DVR) in 57. The mean age was 64 +/- 12 years. Before operation, 80% of the patients were in New York Heart Association functional class III or IV; approximately one-third of the patients had coronary artery disease, and 60 patients had ascending aorta aneurysm. There were 47 operative deaths (AVR, 4%; MVR, 7%; DVR, 10%) and 147 late deaths. Follow-up was complete in 98.6% of the patients and extended from 3 to 140 months (mean, 59 months). At the last follow-up, 84% of the patients were in New York Heart Association class I or II. The actuarial survival at 10 years was 63% +/- 4% for AVR, 55% +/- 5% for MVR, and 53% +/- 9% for DVR. At the end of 10 years, the freedom from thromboembolic complications was 80% +/- 4% for AVR, 88% +/- 3% for MVR, and 86% +/- 5% for DVR; the freedom from endocarditis was 95% +/- 2% for AVR, 96% +/- 1% for MVR, and 87% +/- 5% for DVR; the freedom from primary tissue failure was 92% +/- 3% for AVR, 81% +/- 6% for MVR, and 65% +/- 16% for DVR; and the freedom from reoperation was 89% +/- 2% for AVR, 81% +/- 6% for MVR, and 61% +/- 15% for DVR. The durability of this bioprosthetic valve was affected by the patient's age and by the position where it was implanted. The clinical results of the Hancock II bioprosthesis at 10 years are comparable to those of other current porcine and pericardial valves.
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