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  • Title: [Use of prifinium bromide in endoscopic premedication. A double-blind controlled study vs hyoscine N-butylbromide].
    Author: Magalini M, Monica F.
    Journal: Minerva Gastroenterol Dietol; 1995 Jun; 41(2):197-202. PubMed ID: 7647144.
    Abstract:
    Results are reported of double blind controlled clinical trial in patients to be subjected to gastroduodenoscopy for diagnostic purposes. Before endoscopic examination prifinium bromide or hyoscine N-butylbromide was administered in a single dose intravenously as premedication to 30 out patients randomised into two groups. In order to evaluate the antispasmodic effects of the drugs on the smooth gastroenteric muscle, following endoscopic findings have been examined, before and after administration: gastric peristalsis, pilorus status, duodenum relaxation and duodenal fold morphology. Our data confirm that both drugs induced an appropriate smooth gastroenteric muscle relaxation, enabling an easier endoscopic evaluation. Particularly, patients treated with prifinium bromide pointed out a better response as far as the pilorus status, reaching complete relaxation in 66.7% of subjects versus 26.7% of the control group (p = 0.04). The good tolerability of both drugs is also confirmed.
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