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  • Title: Total but not bioavailable testosterone is a predictor of central adiposity in postmenopausal women.
    Author: Goodman-Gruen D, Barrett-Connor E.
    Journal: Int J Obes Relat Metab Disord; 1995 May; 19(5):293-8. PubMed ID: 7647819.
    Abstract:
    OBJECTIVE: In pre and postmenopausal women low levels of sex hormone binding globulin (SHBG) have been shown to be associated with a large waist-hip ratio (WHR), a measure of visceral adiposity. Previous studies of WHR and testosterone, however, have been inconclusive. DESIGN: We examined the prospective association between endogenous total and bioavailable testosterone and SHBG levels at baseline with WHR measured 12-15 years later in a community-based cohort of older women. SETTING: Rancho Bernardo, California. SUBJECTS: 334 postmenopausal women. MAIN OUTCOME MEASURES: Endogenous total and bioavailable testosterone and SHBG levels and WHR. RESULTS: Only age-adjusted SHBG levels and the testosterone/SHBG ratio were associated with BMI. Age-adjusted SHBG levels and total testosterone decreased with increasing WHR. Neither measured nor estimated (testosterone/SHBG ratio) bioavailable testosterone was associated with WHR before or after adjustment for age, BMI, and cigarette smoking. CONCLUSION: These prospective data confirm the reported cross-sectional association between SHBG and WHR, but show no association with measured bioavailable testosterone or the testosterone/SHBG ratio. These findings do not support the premise that androgens cause visceral adiposity in postmenopausal women.
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