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  • Title: Bupropion/nortriptyline combination for refractory depression.
    Author: Apter JT, Kushner SF, Woolfolk RL.
    Journal: Ann Clin Psychiatry; 1994 Dec; 6(4):255-8. PubMed ID: 7647835.
    Abstract:
    Many patients fail to respond to one or more trials with a single antidepressant. In such cases polypharmacy is often necessary and beneficial, although there may be an increased risk of complications. Four case reports are presented of patients with refractory depression treated successfully with the combination of the tricyclic antidepressant nortriptyline and the newer agent bupropion.
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