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  • Title: Functional liver imaging with asialoglycoprotein receptors and serum hyaluronate in a patient with amyloidosis.
    Author: Hashimoto O, Harada M, Sata M, Imamura K, Matsukuma N, Fukushima H, Itano S, Ohishi M, Ueno T, Iemura A.
    Journal: J Gastroenterol; 1995 Jun; 30(3):403-7. PubMed ID: 7647909.
    Abstract:
    A 47-year-old man with primary amyloidosis was admitted with abdominal pain. A new radionuclide liver imaging technique using Technetium-99m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin, was performed and the serum hyaluronate concentration was measured. Although ordinary laboratory tests revealed only slight abnormalities, the uptake of the radiolabelled ligand for hepatocyte asialo-glycoprotein receptors was decreased, and marked hepatomegaly was revealed. Furthermore, the serum hyaluronate level was elevated. Histological examination of a hepatic needle biopsy specimen revealed a marked deposition of amyloid in the hepatic perisinusoidal spaces. These results indicate that this new radionuclide liver imaging technique (using Technetium-99m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin) and the measurement of serum hyaluronate may be useful supplementary tools for identifying amyloid deposition in the hepatic perisinusoidal spaces in patients with amyloidosis.
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