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  • Title: Effect of D-400, a herbal formulation, on blood sugar of normal and alloxan-induced diabetic rats.
    Author: Anturlikar SD, Gopumadhavan S, Chauhan BL, Mitra SK.
    Journal: Indian J Physiol Pharmacol; 1995 Apr; 39(2):95-100. PubMed ID: 7649614.
    Abstract:
    Blood sugar levels of normal rats treated with D-400 showed significant reduction (P < 0.05) as compared to control groups. The fall was seen at one month and remained so uptill 3 months. Hyperglycemic response to adrenaline was significantly lowered (P < 0.05) following D-400 treatment. D-400 potentiated the hypoglycemia following tolbutamide treatment. Blood sugar remained persistently low in tolbutamide plus D-400 treated group after 3 and 4 hours (P < 0.05). In the alloxan-induced diabetic rats, a significant lowering of blood and urinary sugar was noticed on day 20, 30 and 40 following treatment with D-400 (P < 0.05). Liver glycogen depletion was significantly inhibited in the D-400 treated group (P < 0.025). D-400 has significantly potentiated (P < 0.05) the hypoglycemic action of insulin in alloxan-induced diabetic rats.
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