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  • Title: Xenovulene A, a novel GABA-benzodiazepine receptor binding compound produced by Acremonium strictum.
    Author: Ainsworth AM, Chicarelli-Robinson MI, Copp BR, Fauth U, Hylands PJ, Holloway JA, Latif M, O'Beirne GB, Porter N, Renno DV.
    Journal: J Antibiot (Tokyo); 1995 Jul; 48(7):568-73. PubMed ID: 7649852.
    Abstract:
    Xenovulene A, a novel inhibitor of benzodiazepine binding to the GABA-benzodiazepine receptor is produced by submerged fermentation of Acremonium strictum. It was isolated from the mycelium by solvent extraction and purified by chromatography on Sephadex LH-20 and octadecyl silica. The structure of xenovulene A was determined to be a novel oxygenated sesquiterpene containing a humulene moiety by interpretation of various spectroscopic data, especially from 2D NMR experiments. Xenovulene A inhibited binding of the benzodiazepine, flunitrazepam, with an IC50 of 40 nM in an in vitro assay using bovine synaptosome membrane preparations.
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