These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. II. Structure elucidation.
    Author: Matsuzaki K, Tanaka H, Omura S.
    Journal: J Antibiot (Tokyo); 1995 Jul; 48(7):708-13. PubMed ID: 7649872.
    Abstract:
    The structures of isochromophilones I and II, new gp120-CD4 binding inhibitors isolated from a cultured broth of Penicillium multicolor FO-2338, were elucidated by NMR experiments. Both of compounds have an azaphilone skeleton substituted by a chlorine atom at C-5 and a side chain, 3,5-dimethyl-1,3-heptadien at C-3. Additionally, isochromophilone I has a gamma-lactone ring, and isochromophilone II has 2-oxopropyl moiety instead of a gamma-lactone ring.
    [Abstract] [Full Text] [Related] [New Search]