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  • Title: Efficacy of a temperature-sensitive Sendai virus vaccine in hamsters.
    Author: Tagaya M, Mori I, Miyadai T, Kimura Y, Ito H, Nakakuki K.
    Journal: Lab Anim Sci; 1995 Jun; 45(3):233-8. PubMed ID: 7650890.
    Abstract:
    A temperature-sensitive HVJ-pB strain of parainfluenza type 1 (Sendai) virus was obtained from a persistently virus-infected cell culture. Intranasal inoculation of Syrian hamsters with the HVJ-pB temperature-sensitive mutant resulted in an abortive infection but induced a specific antibody response against Sendai virus without appreciable lesions in the respiratory tract. Prior exposure to the temperature-sensitive mutant protected hamsters from subsequent challenge with virulent wild-type virus. The efficacy of protection became apparent at 5 days after vaccination and lasted for at least 720 days. For practical use of the HVJ-pB vaccine, a single intranasal administration to newborn babies aged over 15 days is recommended.
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