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  • Title: Somatostatin inhibition of insulin and glucagon secretion in rat islet culture: reversal by ionophore A23187.
    Author: Fujimoto WY, Ensinck JW.
    Journal: Endocrinology; 1976 Jan; 98(1):259-62. PubMed ID: 765117.
    Abstract:
    Both insulin and glucagon release by monolayer cell cultures of newborn rat pancreas were increased when calcium concentration was raised from 1.8 mEq/1 to 7.2 mEq/1. In low calcium medium, the calcium ionophore A23187 (10 mug/ml) enhanced insulin and glucagon secretion. Incubation with somatostatin (1.0 mug/ml), which inhibited hormonal release in a low calcium environment, paradoxically caused augmented insulin and glucagon secretion when A23187 was also present.
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