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  • Title: Mechanisms of hearing loss in acoustic neuroma: an otoacoustic emission study.
    Author: Prasher DK, Tun T, Brookes GB, Luxon LM.
    Journal: Acta Otolaryngol; 1995 May; 115(3):375-81. PubMed ID: 7653257.
    Abstract:
    Evoked otoacoustic emissions (EOAE) are active mechanical responses from the cochlea which provide information about the integrity of the preneural cochlear receptor mechanisms. It may be hypothesised, therefore, that if a hearing impairment is neural in origin, normal EOAEs may be obtained from the cochlea, which, although dissociated, is functioning normally. This study examined the status of the cochlea with EOAE in patients with cochlear (Meniere's disease) and neural (surgically proven acoustic neuroma) disease. In patients with presumed cochlear lesions, no emissions were present with mean hearing worse than 40 dB across a frequency range of 0.5 to 4 kHz. Similarly, an EOAE was not present in any of the 26 acoustic neuroma patients studied when the average (0.5 to 4 kHz) hearing was greater than 40 dB. We conclude that dissociation of the cochlea in patients with acoustic neuroma appears to be rare and, in fact, cochlear involvement occurs in most cases. Possible mechanisms responsible for the effect on the cochlea in this group include degenerative changes due to chronic partial obstruction of the blood supply by the tumour, biochemical alterations in the inner ear fluids, loss of efferent control of active mechanical tuning, and hair cell degeneration secondary to neuronal loss in the eighth nerve.
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