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  • Title: Complex of simian virus large T antigen and p53 can bind DNA specifically.
    Author: Long SB, Ho HY, Chen CL, Lai MD.
    Journal: Anticancer Res; 1995; 15(4):1375-80. PubMed ID: 7654024.
    Abstract:
    The DNA-binding activity of p53 was suggested to be abrogated by binding of large T antigen. However we demonstrate that a fraction of p53 can form a complex with large T antigen and still bind DNA specifically. In EMSA analysis, both PAb 416 and 419 anti-large-T antibodies could induce supershift on p53-DNA complex using extracts derived from two T-antigen-transformed cell lines. In EMSA-Western analysis, one of the p53-complexes was shown to contain large T antigen.
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