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  • Title: Bradykinin potentiates acetylcholine induced responses in native endothelial cells from rabbit aorta.
    Author: Wang X, Chu W, Lau F, van Breemen C.
    Journal: Biochem Biophys Res Commun; 1995 Aug 24; 213(3):1061-7. PubMed ID: 7654222.
    Abstract:
    Membrane potential and intracellular [Ca2+] were measured in freshly isolated rabbit aortic endothelial cells. Acetylcholine (10 microM) induced transient membrane hyperpolarization and increased [Ca2+]i. Bradykinin (4 microM) had no direct effect on membrane potential or [Ca2+]i on its own, but potentiated the subsequent ACh response. It changed the usual transient ACh response to a maintained hyperpolarization. The maintained hyperpolarization was blocked by NiCl2 and TEA, indicating an involvement of receptor-operated-Ca2+ channel and Ca2+ -dependent K+ -channel activity. This potentiating effect on bradykinin in isolated cells was confirmed in organ bath studies using isolated aortic rings.
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