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  • Title: Quantification of alpha 1-adrenoceptor subtypes in human tissues by competitive RT-PCR analysis.
    Author: Faure C, Gouhier C, Langer SZ, Graham D.
    Journal: Biochem Biophys Res Commun; 1995 Aug 24; 213(3):935-43. PubMed ID: 7654257.
    Abstract:
    Alpha 1-Adrenoceptors are a heterogeneous subfamily of receptors comprising at least three pharmacologically- and structurally- distinct subtypes named alpha 1a-, alpha 1b- and alpha 1d-adrenoceptors. A competitive reverse transcription-polymerase chain reaction methodology using subtype selective competitor RNAs as reference internal standards was adopted to determine the absolute amounts of each of the three cloned to date alpha 1-adrenoceptor subtype encoding mRNAs in selected human tissues. Our data demonstrated that each of these alpha 1-adrenoceptor subtypes exhibits a distinctive tissular expression pattern.
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