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  • Title: [Monoamine oxidase activity in rat liver in vitamin B12 deficiency].
    Author: Gessler NN, Fedotcheva NI, Foĭgel' AG, Alekseeva NV, Kondrashova MN, Bykhovskiĭ VIa.
    Journal: Biokhimiia; 1995 Jun; 60(6):981-6. PubMed ID: 7654868.
    Abstract:
    Changes in the activity of monoamine oxidase (MAO-B) in liver homogenates and mitochondria from normal and vitamin B12-deficient rats have been studied in various functional states of the mitochondria. Preincubation of liver preparation at 32 degrees C increased the MAO affinity for benzylamine in samples of normal (but not vitamin B12-deficient rats). Succinate added to the incubation medium decreased Km and increased Vmax in both normal and vitamin B12-deficient animals. A correlation was found between the decline of MAO-B activity under vitamin B12 deficiency, deceleration of succinate oxidation and reduction of the transmembrane potential.
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