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  • Title: Effect of disease and drug treatment on blood serotonin and monoamine oxidase B activity in Parkinson's disease.
    Author: van Kempen GM, Janjua R, Roos RA.
    Journal: Clin Neurol Neurosurg; 1995 May; 97(2):131-3. PubMed ID: 7656485.
    Abstract:
    Serotonin (5-hydroxytryptamine, 5HT) content and monoamine oxidase (MAO) activity were determined in whole blood of patients with Parkinson's disease (PD) with and without drug treatment and compared with controls. From that comparison a significant reduction in platelet 5HT became apparent in PD. Selegiline, which was always used in combination with L-dopa, not only inhibited MAO activity, as expected, but it also appeared to induce an increase in 5HT content.
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