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  • Title: [Intrapleural DDP and systemic thiosulfate rescue in the treatment of malignant pleural effusion].
    Author: Hua X, Lu W, Duan G.
    Journal: Zhonghua Zhong Liu Za Zhi; 1995 Jan; 17(1):50-2. PubMed ID: 7656790.
    Abstract:
    One hundred twenty cases of malignant pleural effusion were treated by intrapleural administration of large doses of DDP (500-1,000 mg) followed by iv infusion of sodium thiosulfate for 3 days. Each patient received 1-4 cycles of treatment. Of 120 cases, 89 had their effusion completely disappeared and in 6 of them, it was accompanied by complete regression of tumors in the lung. Partial response was observed in 19 cases with an overall response rate of 90.0%. The median remission period was 6.4 month. Severe (grade III and IV) gastrointestinal, renal toxicity and myelosuppression occurred in 46,8 and 12 cases, respectively, Two patients died of severe intoxication.
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