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  • Title: Identification of Leishmania species by a specific DNA probe that is conserved only in the maxicircle DNA of human-infective Leishmania parasites.
    Author: Lee ST, Chiang SC, Singh AK, Liu HY.
    Journal: J Infect Dis; 1995 Sep; 172(3):891-4. PubMed ID: 7658091.
    Abstract:
    An A + T-rich repeated DNA sequence cloned from maxicircle DNA of Leishmania mexicana amazonensis was found to be conserved in the maxicircles of human-infective Leishmania species but totally absent from non-human-infective ones. Differences in the pattern of distribution of this repeated sequence in the maxicircles of each human-infective Leishmania species potentially allow the development of a sensitive probe to differentiate among these species.
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