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  • Title: Effect of a recent injection of purified protein derivative on diagnostic tests for tuberculosis in cattle infected with Mycobacterium bovis.
    Author: Doherty ML, Monaghan ML, Bassett HF, Quinn PJ.
    Journal: Res Vet Sci; 1995 May; 58(3):217-21. PubMed ID: 7659844.
    Abstract:
    The intradermal injection of avian and bovine purified protein derivative into 15 Mycobacterium bovis-infected cattle reduced the capacity of a second single intradermal comparative tuberculin test carried out seven days later to predict accurately the animals' infection status (P < 0.001). In vitro lymphyocyte blastogenesis was also reduced (P < 0.05) but the in vitro production of interferon-gamma was unaffected.
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