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  • Title: [Changes in cytomembrane and surface cells of the large intestine resulting from the action of sweetening agents].
    Author: Torres de Mercau G, Riera de Martínez Villa N, Mercau GA, Martínez Riera N, Soria de Santos N, Vitalone H.
    Journal: Acta Gastroenterol Latinoam; 1995; 25(1):35-9. PubMed ID: 7660725.
    Abstract:
    Saccharin and cyclamates have been proved to cause organic damage. This work attempt to describe drug-induced changes brought about by drugs in 1/1000 saccharin and cyclamate-fed rats for 90 days. The ultrastructural findings show: microvilli hypertrophy; membranous mitochondrial increase in absorptive cells; and secretion changes in calciform cells. Such changes are cell-response phenomena to interference or mutagenic action on nuclear DNA or on cytoplasmatic metabolism.
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