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  • Title: Effect of topical application of nitroglycerin on cochlear blood flow.
    Author: Ito A, Nakashima T, Yanagita N.
    Journal: Am J Otolaryngol; 1995; 16(3):177-80. PubMed ID: 7661313.
    Abstract:
    PURPOSE: To investigate whether topical application of the vasodilator nitroglycerin would increase cochlear blood flow without adversely affecting inner ear function. MATERIALS AND METHODS: The effect of topical application of nitroglycerin to the round window membrane on cochlear blood flow was measured in 33 guinea pigs with a laser Doppler flowmeter. Endocochlear potential, as an indicator of inner ear function, was recorded by a glass microelectrode inserted through the round window membrane in a second series of 27 guinea pigs. Blood pressure was also monitored in both experiments. RESULTS: Low doses (0.0001 to 1 microgram) of nitroglycerin induced an increase in cochlear blood flow with no change in blood pressure. The cochlear blood flow was maximally increased by approximately 50%. A high dose (50 micrograms) of nitroglycerin induced a significant decrease in blood pressure but did not significantly affect endocochlear potential. CONCLUSIONS: Topical application of nitroglycerin may be useful in increasing cochlear blood flow in various inner ear diseases.
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