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  • Title: [The local anesthetic activity of inclusion compounds of pirbentan and trimecaine with beta-cyclodextrin].
    Author: Kuiantseva AM, Kompantseva EV, Lukashova LA, Zakrzhevskaia TN.
    Journal: Eksp Klin Farmakol; 1995; 58(3):20-2. PubMed ID: 7663287.
    Abstract:
    Whether the prolonged action of the topical anesthetics trimecaine and pirbentan can be achieved by using inclusion compounds was studied. beta-Cyclodextrin was used as an agent containing topical anesthetics in its molecule. In in vitro and in vivo experiments, the inclusion compounds trimecaine and pirbentan with beta-cyclodextrin produced a more prolonged action in terminal anesthesia than the compounds used alone.
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