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  • Title: [The effect of piyavit on hemostatic processes and fibrinolysis in patients with ischemic heart disease].
    Author: Panchenko VM, Serebriakova TN, Podorol'skaia LV, Sorokoletov SM, Dzhanashiia PKh.
    Journal: Eksp Klin Farmakol; 1995; 58(3):28-31. PubMed ID: 7663290.
    Abstract:
    The oral use of the drug Piavit (derived from freeze-dried medicinal leeches) in 50 patients with coronary heart disease for 7 days in a daily dose of 600 mg (20 patients) and 1200 mg (30 patients) caused a moderate dose-independent increase in enzymatic, fibrinolysis, non-enzymatic fibrinolysis and antithrombin III activity. In half the patients who had low fibrinolytic levels, the agent stimulated mainly the release of plasminogen activator on administration days of 2 and 7. In other 15 patients the activity of plasminogen activator remained unchanged, but non-enzymatic fibrinolysis enhanced. Piavit prolonged the hypocoagulative effect of heparin and aspirin in the group of patients pretreated with these drugs. There were no clinical manifestations of the disease during 7 days.
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