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  • Title: [The study of relationship between c-erbB2 expression and cytoimmunology in ovarian carcinoma and its antisense regulation].
    Author: Jin Z, Zhang X, Feng Y.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 1995 Apr; 30(4):222-4. PubMed ID: 7664609.
    Abstract:
    The relationship between c-erbB2 expression and cytoimmunology in ovarian carcinoma cell lines was studied; the synthesized and modified c-erbB2 antisense oligodeoxynucleotide was tested for its ability to reduce over-expression of c-erbB2. The results showed that over-expression of c-erbB2 in ovarian carcinoma could induce resistance to tumor necrosis factor (TNF) and lymphokine activated killer (LAK) cells but had no effect on H2O2; c-erbB2 antisense oligodeoxynucleotide could specifically reduce the over-expression of c-erbB2 and increase the sensitivity of ovarian cancer targets to lysis by TNF and LAK cells.
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