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  • Title: Combined effect of amphotericin B and flucytosine on hyphal growth of Candida albicans estimated at a single hypha level.
    Author: Oh KB, Yang HC, Matsuoka H, Yamamoto A, Kurata H.
    Journal: J Med Vet Mycol; 1995; 33(3):191-5. PubMed ID: 7666300.
    Abstract:
    The in vitro efficacy of amphotericin B and flucytosine, separately and in combination, against the hyphal growth of Candida albicans was evaluated in situ using an automatic analysing system. A colony of C. albicans was in contact with a glucose-salt medium supplemented with biotin plus calf serum (GS medium) and GS medium containing the antifungal agent, in sequence. Minimum inhibitory concentrations at single hyphal level (S-MIC) were determined based on the response that was measured. Amphotericin B S-MICs ranged from 0.8 to 0.4 microgram ml-1, and S-MIC values > 102.4 micrograms ml-1 were obtained with flucytosine when the two agents were used independently. When the two agents were used in combination, however, a synergistic interaction between the two agents at concentrations below their individual S-MICs was observed.
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