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  • Title: [The efficacy of cyclosporin in the treatment of myositis].
    Author: Sánchez Román J, Castillo Palma MJ, Ocaña Medina C, Wichmann I, Chinchón Lara I, Segura Ayestarán DI.
    Journal: Rev Clin Esp; 1995 Jul; 195(7):449-54. PubMed ID: 7667518.
    Abstract:
    Cyclosporin A (CyA) was used in 15 patients with corticosteroid-resistant myositis (11) and as a first-line drug (4). The criterion for improvement was recovery of strength. Additionally, changes in muscle enzyme values were evaluated. One patient left therapy because of gastric intolerance. Another patient, with severe pulmonary fibrosis, died 6 days after initiating therapy. In the other patients a favorable response was observed at approximately six weeks (range 3 weeks-3 months). Significant decreases in muscle enzyme values were observed. CyA was useful for treatment of corticosteroid-resistant patients. While it was efficient as a first line drug, the present report does not allow a comparative evaluation with corticosteroid therapy.
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