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  • Title: Hematopoietic cell transplantation in fetal lambs with ceroid-lipofuscinosis.
    Author: Westlake VJ, Jolly RD, Jones BR, Mellor DJ, Machon R, Zanjani ED, Krivit W.
    Journal: Am J Med Genet; 1995 Jun 05; 57(2):365-8. PubMed ID: 7668364.
    Abstract:
    Hematopoietic cells from the liver of normal 45-48-day-old fetal lambs (Hb type AA) were transplanted intraperitoneally into 58-60-day-old recipient fetuses (Hb type BB). The recipient fetuses resulted from mating homozygous ceroid-lipofuscinosis affected males with heterozygous, phenotypically normal, females. The sex of the donor fetus was also recorded. At age 2 1/2 months the recipient lambs with ceroid-lipofuscinosis were diagnosed by histopathology of brain biopsies. Monitoring of blood and bone marrow cells showed that an average of 9% of blood cells in ceroid-lipofuscinosis affected recipients were of donor origin. No differences were evident in the clinical course of disease, brain weight, or histopathology of organs between transplanted and non-transplanted lambs with ceroid-lipofuscinosis. Under the conditions of this experiment, transplantation of fetal hematopoietic cells was not beneficial.
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