These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of Polyethylene Glycol-Superoxide Dismutase on gastric mucosa and survival in shock with tissue injury.
    Author: Tominaga GT, Bailey S, Daughters K, Sarfeh IJ, Waxman K.
    Journal: Am Surg; 1995 Oct; 61(10):925-9. PubMed ID: 7668470.
    Abstract:
    Oxygen-derived free radicals may play an important role in the pathogenesis of organ injury and death following hemorrhagic shock. This study was designed to test the effects of Polyethylene Glycol-Superoxide Dismutase (PEG-SOD) on gastric mucosal injury and survival in an animal model of hemorrhagic shock and tissue trauma. Reproducible tissue trauma was produced by IM injection of turpentine (1.4 microliters/g). A standardized hemorrhagic shock model with an LD 90 was employed. This model consisted of the following sequence of events: phlebotomy to 60 per cent blood volume, 45-minute shock period, resuscitation using Lactated Ringers (LR) at two times shed volume over 60 minutes. Twenty rats were randomly assigned to receive LR (control) or PEG-SOD (5.36 mg/kg). Immediately following the death or at 72 hours, the stomach was removed. Computer image analysis was used to determine the lesion area as a per cent of total gastric mucosal surface area. Our results show no statistical difference in gastric mucosal lesion area between groups (1.83% vs 1.75%, respectively). Survival at 72 hours was significantly higher for PEG-SOD animals vs controls (70% vs 10%, P = 0.0001). This data suggests that IV administration of PEG-SOD during resuscitation is a potentially effective means of improving survival following severe hemorrhagic shock and tissue injury.
    [Abstract] [Full Text] [Related] [New Search]