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  • Title: Antifungal agents. 10. Synthesis and antifungal activities of aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl) methane derivatives.
    Author: Silvestri R, Pagnozzi E, Troccoli F, Stefancich G, Massa S, Apuzzo G, Perazzi ME, Artico M, Simonetti G.
    Journal: Farmaco; 1995 Apr; 50(4):227-38. PubMed ID: 7669167.
    Abstract:
    Various aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl)methane derivatives have been synthesized and tested as antifungal agents. The new imidazoles have been obtained by the action of 1,1'-sulfinyldiimidazole on aryl-(isoquinolin-1-yl)carbinols, which have been prepared by standard procedures starting from isoquinoline. Among 44 test derivatives only a few have exhibited some antifungal activity, the most active compound (4e) being twofold less potent than miconazole, ketoconazole and bifonazole, used as standard drugs.
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