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  • Title: Identification and characterization of two isoforms of an endothelin-converting enzyme-1.
    Author: Shimada K, Takahashi M, Ikeda M, Tanzawa K.
    Journal: FEBS Lett; 1995 Sep 04; 371(2):140-4. PubMed ID: 7672114.
    Abstract:
    We report the cloning and sequencing of 5'-terminal region of a beta form of rat ECE-1 cDNA which is different only in its N-terminal amino-acid sequence to the cDNA we have cloned previously (alpha form [K. Shimada et al. (1994) J. Biol. Chem. 269, 18275-18278]). No significant difference was found in the specific activity and substrate specificity between the two isoforms. The expression level of ECE-1 alpha mRNA was higher than that of ECE-1 beta in various rat cells and tissues, suggesting that the physiologically important isoform is ECE-1 alpha. The present findings verified the presence of two forms of ECE-1 over many species, which are created probably through alternative splicing.
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