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  • Title: [Model experiments on the effect of IgM- and IgG-antibodies on the reactivity of Treponema pallidum hemagglutination (TPHA)-test].
    Author: Volkerding R, Müller F.
    Journal: Hautarzt; 1976 Jan; 27(1):26-9. PubMed ID: 767301.
    Abstract:
    Fractionated sera of patients in different stages of syphilis were examined comparatively with the TPHA-FTA(IgM)- and FTA(IgG)-test. It was shown that the TPHA-test proved to be convenient for early immunologic diagnosis of syphilis. The TPHA-test includes not only IgG anti-treponemal antibodies but also IgM antibodies. In the early stage of syphilis a reactive result of TPHA-test can be related exclusively on treponemal specific IgM antibodies.
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