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  • Title: Clinical evaluation of extracellular amino acids in severe head trauma by intracerebral in vivo microdialysis.
    Author: Kanthan R, Shuaib A.
    Journal: J Neurol Neurosurg Psychiatry; 1995 Sep; 59(3):326-7. PubMed ID: 7673969.
    Abstract:
    The underlying mechanisms of neuronal dysfunction in head injury are multifactorial and not fully understood. Recent experimental evidence indicates that excitatory amino acids--for example, glutamate--may play a key part in secondary neuronal damage after head injury. A patient with severe head trauma was monitored for extracellular amino acids by intracerebral in vivo microdialysis. Very high concentrations of glutamate, glycine, and gamma-aminobutyric acid were recorded in the microdialysate specimens collected over three hours. In vivo microdialysis in head injury may prove to be a useful tool in understanding the pathogenesis of cell death in head trauma.
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