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  • Title: Microwave-induced organic reactions of bile acids: esterification, deformylation and deacetylation using mild reagents.
    Author: Dayal B, Rao K, Salen G.
    Journal: Steroids; 1995 Jun; 60(6):453-7. PubMed ID: 7676478.
    Abstract:
    An efficient and convenient procedure for the esterification, deformylation, and deacetylation of bile acids is described. This is achieved by the addition of a catalytic amount of methanesulfonic acid or para-toluene sulfonic acid to a solution of bile acid in methanol in the domestic microwave oven. All these reactions were completed in the microwave oven within 1-3 min at 60% power (390 W) and the desired bile acids, namely trihydroxy-5 beta-cholestanoic acid, (23R)-3 alpha,7 alpha,23-trihydroxy-5 beta-cholan-24-oic acid, ursocholic acid and 7-ketolithocholic acid were isolated in 86-94% yield.
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