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  • Title: Chromosomal aberrations induced in vitro by 3,7- and 3,9-dinitrofluoranthene.
    Author: Matsuoka A, Horikawa K, Yamazaki N, Sera N, Sofuni T, Tokiwa H.
    Journal: Mutat Res; 1993 Feb; 298(4):255-9. PubMed ID: 7678161.
    Abstract:
    The chromosomal aberration test using a Chinese hamster cell line (CHL) was carried out with 3,7- and 3,9-dinitrofluoranthene (DNF) with and without exogenous metabolic activation (rat liver S9 mix). The highest dose tested was limited to 20 micrograms/ml because of the compounds' insolubility in dimethyl sulfoxide. Both DNFs induced chromosomal aberrations in the absence of S9 mix; the frequency was not very high. Results were reproducible, but without clear dose-response relationships. Neither DNF induced chromosomal aberrations in the presence of S9 mix. Both DNFs did not induce polyploid cells under any conditions.
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