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  • Title: Regional localization of the human vitronectin receptor alpha subunit gene (VNRA) to chromosome 2q31-->q32.
    Author: Fernández-Ruiz E, Pardo-Manuel de Villena F, Rodríguez de Córdoba S, Sánchez-Madrid F.
    Journal: Cytogenet Cell Genet; 1993; 62(1):26-8. PubMed ID: 7678549.
    Abstract:
    The vitronectin receptor (av:beta 3; CD51/CD61), a member of the beta 3 integrin subfamily (cytoadhesins), functions as a receptor for a group of proteins that includes vitronectin, fibrinogen, thrombospondin, and von Willebrand factor. The human locus for the av gene (VNRA) was previously mapped to the long arm of chromosome 2 by DNA analysis of somatic cell hybrids. By using fluorescence in situ hybridization, coupled with GTG-banding, we have regionally mapped the human av gene to chromosome 2q31-->q32. An identical location was previously reported for the human gene coding for the integrin VLA-alpha 4 subunit (CD49D). These data, therefore, suggest the existence of a cluster of integrin genes at this chromosomal location.
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