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  • Title: Inhibition of yeast cytochrome P-450 by ammonium metavanadate.
    Author: Del Carratore R, Morichetti E, Galli A, Galeotti C, Bronzetti G.
    Journal: Mutat Res; 1993 Mar; 301(3):165-70. PubMed ID: 7679198.
    Abstract:
    Incubation of diploid D7 strain cells of Saccharomyces cerevisiae (grown in 20% glucose) in the presence of ammonium metavanadate (AMV) led to a decrease in the cytochrome P-450-dependent monooxygenase system (cytochrome P-450 level and 7-ethoxycoumarin O-deethylase). The electrophoretic analysis of microsomal fractions of yeast cells treated with metavanadate revealed a decrease in the intensity of the bands corresponding to a M(r) in the range of 51,000-58,000 Da compared with those observed in controls, i.e., cells grown in 20% glucose. Analysis of the cytochrome P-450 transcript showed that AMV treatment reduced the mRNA level. Our results suggest that AMV inhibits the yeast cytochrome P-450 system by acting at both the pre- and post-transcriptional levels.
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