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  • Title: 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells.
    Author: Kooyman AR, van Hooft JA, Vijverberg HP.
    Journal: Br J Pharmacol; 1993 Feb; 108(2):287-9. PubMed ID: 7680589.
    Abstract:
    Effects of 5-hydroxyindole (5-OHi) on 5-HT3 receptor-operated ion current were investigated in voltage-clamped N1E-115 neuroblastoma cells. In the presence of 1 mM 5-OHi, the amplitudes of inward currents induced by the agonists 5-hydroxytryptamine (5-HT), 2-methyl-5-HT and dopamine were enhanced and desensitization of the responses was markedly slowed down. The results indicate that 5-OHi selectively modifies the desensitization of the 5-HT3 receptor-mediated ion current.
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