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  • Title: Receptor sites for open channel blockers of Shaker voltage-gated potassium channels--molecular approaches.
    Author: Pongs O.
    Journal: J Recept Res; 1993; 13(1-4):503-12. PubMed ID: 7680721.
    Abstract:
    The Shaker locus encodes a family of voltage-gated potassium (K) channels expressed in the central and peripheral nervous system as well as in muscle. Members of the Shaker K-family have variant amino- and carboxy-terminal sequences, which assemble into homo- and hetero-multimeric K-channels. The channels have distinct kinetics of activation and inactivation. Electrophysiological characterization of wild type and mutant K-channels allows to correlate particular domains and critical amino acid residues with receptor sites of open channel blockers such as tetraethylammonium, charybdotoxin and dendrotoxin.
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