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  • Title: Primary structure and functional expression of a mouse inward rectifier potassium channel.
    Author: Kubo Y, Baldwin TJ, Jan YN, Jan LY.
    Journal: Nature; 1993 Mar 11; 362(6416):127-33. PubMed ID: 7680768.
    Abstract:
    A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.
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