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  • Title: Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia.
    Author: Baranger L, Gardembas M, Hillion J, Foussard C, Ifrah N, Boasson M, Berger R.
    Journal: Genes Chromosomes Cancer; 1993 Feb; 6(2):118-20. PubMed ID: 7680887.
    Abstract:
    Acute promyelocytic leukemia (APL) is usually associated with the translocation t(15;17)(q22;q12-21), which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a patient with typical APL without the common t(15;17). Cytogenetic studies demonstrated a normal appearance of chromosomes 15, while a small marker seemed to be an i(17q-). Molecular analysis showed RARA and PML rearrangements, suggesting that the chromosome abnormality corresponded to a variant translocation.
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