These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of selenium and protein deficiency on selenium and glutathione peroxidase in rats.
    Author: Zhu Z, Kimura M, Itokawa Y.
    Journal: Biol Trace Elem Res; 1993 Jan; 36(1):15-23. PubMed ID: 7681678.
    Abstract:
    Twenty-four weanling male Wistar rats were divided into four groups fed diets containing adequate or deficient levels of selenium (0.5 ppm [+Se] or < 0.02 ppm [-Se] and protein (15% [+Pro] or 5% [-Pro]), but adequate levels of all other nutrients for 4 wk to determine the effects of Se deficiency and protein deficiency on tissue Se and glutathione peroxidase (GSHPx) activity in rats. Plasma, heart, liver, and kidney Se and GSHPx were significantly lower in Se-deficient groups in relation to Se-sufficient groups. In Se-deficient groups, Se and GSHPx were significantly higher in -Se-Pro rats in heart, liver, and kidney. Data analysis showed that there were significant interaction effects between dietary Se and protein on Se and GSHPx of rats. It is assumed that under the condition of Se deficiency, a low level of protein may decrease Se and GSHPx utilization, increase GSHPx synthesis, and result in Se redistribution. This could account for high levels of Se and GSHPx in the -Se-Pro rats compared to -Se+Pro rats.
    [Abstract] [Full Text] [Related] [New Search]