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  • Title: A monoclonal antibody produced during infection which recognizes an epitope of influenza hemagglutinin only in the context of H-2k MHC class I antigen.
    Author: McLain L, Dimmock NJ.
    Journal: J Immunol; 1993 Apr 15; 150(8 Pt 1):3421-6. PubMed ID: 7682240.
    Abstract:
    A hybridoma prepared from cells isolated from the lungs of H-2k mice infected with influenza virus (A/WSN) produces a monoclonal IgM (LM41) which recognizes an epitope of the A/WSN hemagglutinin (HA) Ag only when it is expressed in H-2k cells, as shown by Ag binding and complement-mediated lysis. However, it did not bind to the native HA of virus particles or any form of HA protein present on A/WSN-infected H-2d cells. LM41 inhibited Ag-specific, MHC class I-restricted lysis of H-2k target cells infected with a vaccinia recombinant virus expressing the HA of A/WSN by CTL from A/WSN virus-infected H-2k mice. We conclude that LM41 has a similar Ag specificity to the HA-specific TCR.
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